Multiple and Contemporary Coronary Thrombosis inspite of Low Platelet Function Response
نویسندگان
چکیده
منابع مشابه
Multiple coronary thrombosis
We read the article “Simultaneous thrombosis of multiple coronary arteries in a patient with rheumatoid arthritis” by Kalayci et al1 with great interest. The authors presented a patient with rheumatoid arthritis treated by methotrexate developing ST segment elevation myocardial infarction. We commend the authors for this interesting report and want to make some comments. Between the three optio...
متن کاملPlatelet Function in Thrombosis and Hemostasis.
Platelets represent the main effectors in the formation of the initial hemostatic plug through an elaborate response to vascular injury, and furthermore, platelets play an essential role in secondary hemostasis.1 However, platelets are also important contributors to pathological thrombus formation and vessel occlusion when activated inappropriately. Moreover, platelets contribute to processes b...
متن کاملPlatelet aggregation inhibitors in prevention and treatment of coronary thrombosis.
Platelet aggregation plays a key role in the development of complications of atherosclerosis. By inhibiting platelet aggregation in a pharmacological way complications such as myocardial infarction and sudden death may be prevented. This goes for primary as well as secondary prevention. The most relevant substances for this goal are aspirin, clopidogrel and the new glycoprotein IIb/IIIa inhibit...
متن کاملCoronary thrombosis and the platelet glycoprotein IIIA gene PLA2 polymorphism.
Myocardial infarction results from a platelet-rich occlusive coronary thrombus. Platelet membrane glycoprotein IIb/IIIa plays an important role in platelet adhesion and aggregation. Two polymorphisms of the gene encoding the IIIa subunit. PLA1 and PLA2, have been identified. We investigated the frequency of these polymorphisms in 114 consecutive patients with a history of angina-like chest pain...
متن کاملGSK3beta is a negative regulator of platelet function and thrombosis.
Glycogen synthase kinase (GSK)3beta is a ser-thr kinase that is phosphorylated by the kinase Akt. Although Akt has been shown to regulate platelet function and arterial thrombosis, its effectors in platelets remain unknown. We show here that agonist-dependent phosphorylation of GSK3beta in platelets is Akt dependent. To determine whether GSK3beta regulates platelet function, platelets from mice...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: JOURNAL OF CLINICAL AND DIAGNOSTIC RESEARCH
سال: 2014
ISSN: 2249-782X
DOI: 10.7860/jcdr/2014/7811.4657